​Helle Pappot is a senior consultant at the Department of Oncology, Copenhagen University Hospital – Rigshospitalet, and Professor of Clinical Oncology at the University of Copenhagen, with a particular focus on patient involvement and Patient-Reported Outcomes (PRO). Her career spans extensive clinical practice and research, bridging close patient contact with the translation of new knowledge into everyday care.
Her research uses both qualitative and quantitative methods and includes quality-of-life research, PRO measurement, and the implementation of digital health solutions in cancer care. Her primary focus is adolescents and young adults (AYA) with cancer, including their quality of life, psychosocial needs, and improved continuity across the cancer trajectory and follow-up.
She leads Rigshospitalet’s Kræftværket research group and co-developed the UngeKræfter app with young people with cancer through a co-creation process; the solution is now implemented nationally in Denmark. She is also involved in several ongoing national and international research projects within AYA oncology.
Helle Pappot is the founder and leader of NAYAcareDK, a national research network about - and with - young adults with cancer, and she actively contributes to international PRO collaborations, including the EORTC Quality of Life Group. She collaborates with the National Cancer Institute (USA) and with PRO researchers and networks in Austria, England, the Netherlands, Switzerland, and Poland. Furthermore, she serves as Deputy Chair of the DCCC’s Scientific Committee and as Chair of Medical Research Ethics Committee 1.

1. Sodergren SC, Husson O, Janssen S, Rohde GE, Hossain MJ, Abaza H, Alkan A, Al-Omari A, Ben-Aharon I, Bentsen L, Guren MG, Ioannidis G, Ishiki H, Koehler M, Lidington E, Lugowska I, McDonald F, Krishnamurthy MN, Korenblum C, Majorana A, Memos N, Otth M, Pappot H, Pérez-Campdepadrós M, Petranovic D, Richter D, Roganovic J, Scheinemann K, Sikora-Koperska A, Stark D, Stavrou N, Turhal S, Winterling J, Yarom N, Darlington AE; EORTC Quality of Life Group. Development of a Health-Related Quality of Life Tool for Adolescents and Young Adults With Cancer. JAMA Netw Open 2025;8(12):e2549071. doi: 10.1001/jamanetworkopen.2025.49071. PMID: 41632126.
2. ​Wintner LM, Sztankay M, Abdel-Razeq H, Hamdan-Mansour R, Caocci G, Mouillet G, Kikawa Y, Shibata N, Krishnamurthy MN, Joshi A, Krishnatry R, Jain A, Pappot H, Petranović D, Trobentar A, Schmidt H, Schulze S, Tararykova A, Zabernigg A, Giesinger JM, Holzner B; EORTC Quality of Life Group. Inter-rater reliability of CTCAE assessments with or without EORTC patient-reported outcome data in a mixed cancer population: a multinational, open-label, randomised controlled trial. Lancet Oncol 2026;27(2):233-242. doi: 10.1016/S1470-2045(25)00679-5. PMID: 41570841.
   
3. Aagesen M, Pappot H, Piil K, Frøding LP, Steen-Olsen EB, Greimel E, Bentsen L. Exploration of the relevance and comprehensibility of the European Organization for the Research and Treatment of Cancer Sexual Health Questionnaire among Danish young adults aged 18-39: a national cross-sectional study. J Patient Rep Outcomes 2025;10(1):3. doi: 10.1186/s41687-025-00988-w. PMID: 41474473.
   
4. Tolstrup LK, Rasmussen IL, Pappot H. Insights from using patient-reported outcomes as an intervention during cancer treatment in Denmark: potential reasons for limited effectiveness. Health Qual Life Outcomes 2025;23(1):85. doi: 10.1186/s12955-025-02417-4. PMID: 40993731.
   
5. Steen-Olsen EB, Pappot H, Hjerming M, Hanghoej S, Holländer-Mieritz C. Monitoring Adolescent and Young Adult Patients With Cancer via a Smart T-Shirt: Prospective, Single-Cohort, Mixed Methods Feasibility Study (OncoSmartShirt Study). JMIR Mhealth Uhealth 2024;12:e50620. doi: 10.2196/50620. PMID: 38717366.
   
6. Pappot H, Taarnhøj GA, Bentsen L, Friis RB, Bæksted C, Christiansen MG, Holländer-Mieritz C, Møller PK, Rasmussen IML, Lund-Jacobsen T, Stormoen DR, Tolstrup LK. Patient-reported outcomes used actively in cancer patients undergoing antineoplastic treatment: A mini-review of the Danish landscape. Comput Struct Biotechnol J 2023;24:23-30. doi: 10.1016/j.csbj.2023.11.054. PMID: 38076643.
   
7. Pappot H, Meier SK, Hjerming M, Piil K, Hanghøj S. Research involvement and engagement of adolescent and young adults in a cancer trajectory: a 5-year experience from a patient support facility at a university hospital. Res Involv Engagem 2023;9(1):56. doi: 10.1186/s40900-023-00464-z. PMID: 37480141.
   
8. Beauchamp UL, Pappot H, Holländer-Mieritz C. The use of wearables in clinical trials during cancer treatment: systematic review. JMIR Mhealth Uhealth 2020;8(11):e22006. doi: 10.2196/22006. PMID: 33174852.
   
9. Hanghøj S, Boisen KA, Hjerming M, Elsbernd A, Pappot H. Usability of a mobile phone app aimed at adolescents and young adults during and after cancer treatment: qualitative study. JMIR Cancer 2020;6(1):e15008. doi: 10.2196/15008. PMID: 31895046.
   
10. Pappot H, Assam Taarnhøj G, Elsbernd A, Hjerming M, Hanghøj S, Jensen M, Boisen KA. Health-related quality of life before and after use of a smartphone app for adolescents and young adults with cancer: pre-post interventional study. JMIR Mhealth Uhealth 2019;7(10):e13829. doi: 10.2196/13829. PMID: 31584008.​​​